A set of eleven manuscripts in Science, Science Translational Medicine and Science Advances is the culmination of work by the PsychENCODE Consortium to provide an enhanced framework of regulatory genomic elements in individuals with neuropsychiatric disorders. Together these manuscripts provide new insights into the biology of the human brain based on analysis of transcriptomic, epigenomic, and genomic data from post-mortem adult and developing human brains, and human cellular model systems. The manuscripts are organized around three flagship articles, the first analyzing human development, the second studying disease transcriptomes, and the third integrating tissue and single-cell data with deep-learning approaches.
Revealing the brain’s molecular architecture – Introduction to special issue
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Integrative Functional Genomic Analysis of Human Brain Development and Neuropsychiatric Risk Li et al.
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Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder Gandal et al.
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Comprehensive functional genomic resource and integrative model for the human brain Wang et al.
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Spatiotemporal transcriptomic divergence across human and macaque brain development Zhu et al.
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Transcriptome and epigenome landscape of human cortical development modeled in brain organoids Amiri et al.
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Neuron-specific Signatures in the Chromosomal Connectome Associated with Schizophrenia Risk Rajarajan et al.
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Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder An et al.
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Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation Rhie et al.
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A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons Kozlenkov et al.
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The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders Chen et al.
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The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes Meng et al.
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