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A set of eleven manuscripts in Science, Science Translational Medicine and Science Advances is the culmination of work by the PsychENCODE Consortium to provide an enhanced framework of regulatory genomic elements in individuals with neuropsychiatric disorders. Together these manuscripts provide new insights into the biology of the human brain based on analysis of transcriptomic, epigenomic, and genomic data from post-mortem adult and developing human brains, and human cellular model systems. The manuscripts are organized around three flagship articles, the first analyzing human development, the second studying disease transcriptomes, and the third integrating tissue and single-cell data with deep-learning approaches.

Revealing the brain’s molecular architecture – Introduction to special issue

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